Important notice

These pages present the Plasmodesma serveur which is currently under continuous development.

The service provided on internet is meant to be improved regularly, both by the extension of the analytical methods and addition of new methods, but also by input from the users of the service, and in articular from remarks that will be discussed during the Faraday meeting.


This Web service allows to use the *Plasmodesma* server freely

When using this service, please refer to:

This site is associated to the work:

Automatised Pharmacophoric Deconvolution of Plant Extracts, application to Cinchona bark crude extract

Laure Marguerittea‡, Laura Ducielb,c‡, Mélanie Bourjotd, Catherine Vonthron-Sénécheaua, and Marc-André Delsuc∗b

  • a. Laboratoire d’Innovation Thérapeutique (LIT) UMR CNRS 7200, LabEx Medalis, Faculté de Pharmacie, Université de Strasbourg, Illkirch-Graffenstaden, France
  • b. CASC4DE Le Lodge, 20, Avenue du Neuhof, 67100 Strasbourg, France
  • c. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U596, CNRS UMR 7104, Université de Strasbourg, Illkirch-Graffenstaden, France
  • d. Institut Pluridisciplinaire Hubert Curien (IPHC) UMR CNRS 7178, Faculté de Pharmacie, Université de Strasbourg, Illkirch-Graffenstaden, France.
‡ These two authors contributed equally

Faraday Discuss., 2019, Accepted Manuscript | 10.1039/C8FD00242H


We present a development of the *Plasmodesma* dereplication method [Margueritte et al., Magn. Reson. Chem., 2018 56, 469]. This method is based on the automatic acquisition of a standard set of NMR experiments from a medium size set of samples differing by their bioactivity. From this raw data, an analysis pipeline is run and the data is analysed by leveraging machine learning approaches in order to extract the spectral fingerprints of the active compounds. The optimal conditions for the analysis are determined, and tested on two different system, a synthetic sample where a single active molecule is to be isolated and characterized, and a complex bioactive matrix with synergetic interactions between the components. The method allows the identification of the active compounds and performs a pharmacophoric deconvolution.

The program is made available on internet, with an interactive visualisation of the statistical analysis, at

To process a data-set


This program is available here:


This sever is made possible thanks to the help of many people and organisations.

We thanks